Eularian wall film model for predicting dynamic cell culture process to evaluate scaffold design in a perfusion bioreactor

In tissue engineering field, it is important to develop a suitable numerical model evaluate scaffold geometry design. The experimental evaluation of the effect each specific parameter on regeneration requires large cost and long time expend. Dynamic cell culture commonly used for generating tissues which could replace damaged tissues. A perfusion bioreactor developed able simulate dynamic culture, quality. wall-film attachment with assumption that cells be seen as liquid drops. process attachment, impinge solid surface form film were considered attached surface. Two types cell-scaffold interactions involved in models including trap Stanton-Rutland (Cell model—CIM) model. For model, all impinged are attached. four regimes interaction stick, rebound, spread, splash, only stick spread By comparison two different methods, results showed CIM result more related than indicated occurred process. evaluating scaffold's seeding by these models, further this use assessing